1227780-10-0

Basic information

• Product Name: 1-(2-(3-(1-(1-benzylpyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)propylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea
• Synonyms: 1-(2-(3-(1-(1-benzylpyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)propylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea
• CAS NO: 1227780-10-0
• Molecular Weight: 664.811
• Mol File: 1227780-10-0.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-(3-(1-(1-benzylpyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)propylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(3-(1-(1-benzylpyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)propylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea(1227780-10-0)
• EPA Substance Registry System: 1-(2-(3-(1-(1-benzylpyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)propylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea(1227780-10-0)

Safety Data

• Hazardous Substances Data: 1227780-10-0(Hazardous Substances Data)

Upstream product

• 1227780-08-6 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea 

Relevant articles and documents

Synthesis and biological evaluation of a triazole-based library of pyrido[2,3-d]pyrimidines as FGFR3 tyrosine kinase inhibitors

A library of pyrido[2,3-d]pyrimidines was designed as inhibitors of FGFR3 tyrosine kinase allowing possible interactions with an unexploited region of the ATP binding-site. This library was built-up with an efficient step of click-chemistry giving easy access to triazole-based compounds bearing a large panel of substituents. Among the 27 analogues synthesized, more than half exhibited 55-89% inhibition of in vitro FGFR3 kinase activity at 2 μM and one (19g) was able to inhibit auto-phosphorylation of mutant FGFR3-K650M in transfected HEK cells.