1227780-20-2Relevant academic research and scientific papers
Synthesis and biological evaluation of a triazole-based library of pyrido[2,3-d]pyrimidines as FGFR3 tyrosine kinase inhibitors
Le Corre, Laurent,Girard, Anne-Lise,Aubertin, Johannes,Radvanyi, Franois,Benoist-Lasselin, Catherine,Jonquoy, Aurelie,Mugniery, Emilie,Legeai-Mallet, Laurence,Busca, Patricia,Le Merrer, Yves
supporting information; experimental part, p. 2164 - 2173 (2010/07/04)
A library of pyrido[2,3-d]pyrimidines was designed as inhibitors of FGFR3 tyrosine kinase allowing possible interactions with an unexploited region of the ATP binding-site. This library was built-up with an efficient step of click-chemistry giving easy access to triazole-based compounds bearing a large panel of substituents. Among the 27 analogues synthesized, more than half exhibited 55-89% inhibition of in vitro FGFR3 kinase activity at 2 μM and one (19g) was able to inhibit auto-phosphorylation of mutant FGFR3-K650M in transfected HEK cells.
