1227785-60-5

Basic information

• Product Name: C₃₇H₆₃N₅O₇S
• CAS NO: 1227785-60-5
• Molecular Weight: 722.003
• Mol File: 1227785-60-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₆₃N₅O₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₆₃N₅O₇S(1227785-60-5)
• EPA Substance Registry System: C₃₇H₆₃N₅O₇S(1227785-60-5)

Safety Data

• Hazardous Substances Data: 1227785-60-5(Hazardous Substances Data)

Upstream product

• 1229337-32-9 C₂₆H₄₅N₃O₆S 

Relevant articles and documents

Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups

Blood borne hepatitis C infections are the primary cause for liver cirrhosis and hepatocellular carcinoma. HCV NS3 protease, a pivotal enzyme in the replication cycle of HCV virus has been the primary target for development of new drug candidates. Boceprevir and telaprevir are two novel ketoamide derived inhibitors that are currently undergoing phase-III clinical trials. These inhibitors include ketoamide functionality as serine trap and have an acidic alpha-ketoamide center that undergoes epimerization under physiological conditions. Our initial attempts to arrest this epimerization by introducing quaternary amino acids at P1 had resulted in significantly diminished activity. In this manuscript we describe alpha quaternized P1 group that result in potent inhibitors in the enzyme assay and demonstrate cellular activity comparable to boceprevir.