1227796-18-0

Basic information

• Product Name: 5-(4-methylphenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidine-2,4,7-trione
• Synonyms: 5-(4-methylphenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidine-2,4,7-trione
• CAS NO: 1227796-18-0
• Molecular Weight: 272.263
• Mol File: 1227796-18-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-(4-methylphenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidine-2,4,7-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methylphenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidine-2,4,7-trione(1227796-18-0)
• EPA Substance Registry System: 5-(4-methylphenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidine-2,4,7-trione(1227796-18-0)

Safety Data

• Hazardous Substances Data: 1227796-18-0(Hazardous Substances Data)

Upstream product

• 67-52-7 BARBITURIC ACID 
• 104-87-0 4-methyl-benzaldehyde 
• 57-13-6 urea 
• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 

Relevant articles and documents

An operationally simple green procedure for the synthesis of dihydropyrimido[4,5-d] pyrimidinetriones using CuI nanoparticles as a highly efficient catalyst

A green, efficient and simple protocol was developed for the synthesis of dihydropyrimido[4,5-d] pyrimidinetrione derivatives via a coupling reaction of 6-aminouracils, aromatic aldehydes and urea in aqueous media in the presence of nano-crystalline CuI a

Green Synthesis of Copper Oxide Nanoparticles with an Extract of Euphorbia maculata and Their Use in the Biginelli Reaction

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One pot synthesis of spiro pyrimidinethiones/spiro pyrimidinones, quinazolinethiones/quinazolinones, and pyrimidopyrimidines

(Chemical Equation Presented) Condensation of cyclohexane-1,3-dione/ barbituric acid, thiourea/urea, and aromatic aldehyde in the mole ratio of 1:1:3 in solventless reaction in presence of NiCl2/KI afforded 1,5-diaryl-3-thioxo-2,4-diazaspiro[5.5]undecane-7,11-dione/1,5-diaryl-2, 4-diazaspiro[5.5]undecane-3,7,11-trione analogues and 7,11-diaryl-9-thioxo-2,4, 8,10-tetraazaspiro[5.5]undecane-1,3,5,-trione/7,11-diaryl-2,4,8, 10-tetraazaspiro[5.5] undecane-1,3,5,9-tetraone analogues, respectively. The similar condensation of cyclohexane-1,3-dione/cyclohexanone, thiourea/urea, and aromatic aldehyde/heteroaromatic aldehyde in the mole ratio of 1:1:1 in refluxing methanol afforded 4-aryl/heteroaryl-2-thioxo-1,2,3,4,5,6,7,8- octahydroquinazolin-5-one, 4-aryl/heteroaryl-1,2,3,4,5,6,7,8- octahydroquinazoline-2,5-dione analogues and 4-aryl/heteroaryl-1,2,3,4,5, 6,7,8-octahydroquinazoline-2-thione, 4-aryl/heteroaryl-1,2,3,4,5,6,7,8- octahydroquinazolin-2-one analogues, respectively. Condensation of heterocyclic active methylene compound, barbituric acid, thiourea/urea, and aromatic aldehydes under similar set of conditions in 1:1:1 mole ratio was carried which afforded 5-aryl-7-thioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidine-2,4- dione/5-aryl-1,2,3,4,5, 6,7,8-octahydropyrimido[4,5-d]pyrimidine-2,4,7-trione analogues. Similar condensation of an active methine compound, 2-acetylcyclohexanone, thiourea/urea, and aromatic aldehydes in the mole ratio of 1:1:1 produced 5-aryl-1-methyl-3-thioxo-2,4-diazaspiro[5.5]undec-1-en-7-one/ 5-aryl-1-methyl-2, 4-diazaspiro[5.5]undec-1-ene-3, 7-dione analogues, the spiro compounds of entirely different kind. All these identifications and characterizations have been based on the elemental analysis and spectral data.