1227798-49-3

Upstream product

• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 
• 939-52-6 4-chloro-1-phenylbutan-1-one 

Downstream Products

• 1227798-53-9 C₁₄H₂₂ClNOS 
• 1227798-59-5 C₁₄H₂₂ClNOS 
• 1227798-63-1 (S)-1-((R)-2-methylpropane-2-sulfinyl)-2-phenylpyrrolidine 
• 860640-20-6 (R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-phenyl-pyrrolidine 

Relevant academic research and scientific papers

Synthesis of nitrogenated heterocycles by asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)haloimines

Highly optically enriched, protected, nitrogenated heterocycles with different ring sizes have been synthesized by a very efficient methodology consisting of the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl) haloimines followed by treatment with a base to promote an intramolecular nucleophilic substitution process. N-Protected aziridines, pyrrolidines, piperidines, and azepanes bearing aromatic, heteroaromatic, and aliphatic substituents have been obtained in very high yields and diastereomeric ratios up to >99:1. The free heterocycles can be easily obtained by a simple and mild desulfinylation procedure. Both enantiomers of the free heterocycles can be prepared with the same good results by changing the absolute configuration of the sulfur atom of the sulfinyl group.

Asymmetric synthesis of 2-arylpyrrolidines starting from γ-chloro N-(tert-butanesulfinyl)ketimines

The enantioselective reductive cyclization of γ-chloro N-(tert-butanesulfinyl)ketimines towards the short and efficient synthesis of (S)- and (R)-2-arylpyrrolidines (ee >99%) is described for the first time by treatment with LiBEt3H and subsequ