1227808-95-8

Basic information

• Product Name: 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)-methyl)-5-(5-fluoropyrimidin-2-yl)benzamide
• Synonyms: 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)-methyl)-5-(5-fluoropyrimidin-2-yl)benzamide
• CAS NO: 1227808-95-8
• Molecular Weight: 399.8
• Mol File: 1227808-95-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)-methyl)-5-(5-fluoropyrimidin-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)-methyl)-5-(5-fluoropyrimidin-2-yl)benzamide(1227808-95-8)
• EPA Substance Registry System: 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)-methyl)-5-(5-fluoropyrimidin-2-yl)benzamide(1227808-95-8)

Safety Data

• Hazardous Substances Data: 1227808-95-8(Hazardous Substances Data)

Upstream product

• 1227808-42-5 1-(aminomethyl)-4,4-difluorocyclohexanol 
• 1227807-75-1 C₁₁H₆ClFN₂O₂ 

Relevant articles and documents

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X7 receptor.