1227872-99-2Relevant academic research and scientific papers
Synthesis and tuberculostatic activity of novel 1,2,4-triazoles obtained from heterocyclic carbohydrazides
Gobis, Katarzyna,Foks, Henryk,Zwolska, Zofia,Augustynowicz-Kope, Ewa
, p. 917 - 934 (2010)
The novel 1,2,4-triazole derivatives have been synthesized by a few different pathways. Heterocyclic carbohydrazides were used to obtain monoesters of hydrazine acids (16), thiosemicarbazide derivatives (717), and finaly 1,2,4-triazole-5-thiones (1838). Carbohydrazides were also cyclized with methyl carbamodithioates in the presence of DBU giving 1,2,4-triazole-5-thiones (18, 19, 3947). Two of final products (39, 40) were undergone alkylation in alkaline solution to appropriate sulfides (4853). Then methylsulfides (48, 49) were oxidized with peroxyacetic acid to sulfoxides (54, 55). The obtained compounds were tested in vitro towards Mycobacterium tuberculosis.
