12279-41-3

Basic information

• Product Name: Seractide
• Synonyms: CORTICOTROPIN (HUMAN);CORTICOTROPHIN;CORTICOTROPIN A;H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE-OH;ACTH (1-39), HUMAN;ACTH 1-39;ACTH;ADRENOCORTICOTROPIC HORMONE HUMAN
• CAS NO: 12279-41-3
• Molecular Formula: C207H308N56O58S1
• Molecular Weight: 4541.07
• EINECS: 232-659-7
• Product Categories: Peptide;Melanocortin receptor
• Mol File: 12279-41-3.mol
• Article Data: 0

Chemical Properties

• Appearance: White lyophilised solid
• Storage Temp.: −20°C
• Solubility: H2O: 1 mg/mL, clear, colorless
• CAS DataBase Reference: Seractide(CAS DataBase Reference)
• NIST Chemistry Reference: Seractide(12279-41-3)
• EPA Substance Registry System: Seractide(12279-41-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: GM7900000
• F: 8-10
• Hazardous Substances Data: 12279-41-3(Hazardous Substances Data)

Usage

Uses

Hormone (adrenocorticotropic).

Brand name

Acthar Gel-Synthetic (Armour).

General Description

Adrenocorticotropic hormone (ACTH) is a 303-amino acid hormone protein, which is located at human chromosome 2p23.3.

Biochem/physiol Actions

Adrenocorticotropic hormone (ACTH) stimulates melanocortin receptor (MC1R to MC5R).It is implicated in the production of α-melanocyte-stimulating hormone (α-MSH). Hypomethylation of ACTH promoter region in thymic carcinoids is associated with ectopic adrenocorticotropic hormone syndrome. Mutations in this gene are associated with aberrant fusion protein and impairing melanocortin signaling in hypoadrenalism. Dysregulation of ACTH leads to Cushing disease.