1227911-51-4

Basic information

• Product Name: 3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
• Synonyms: 3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole;3-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-indazole;3-methyl-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole;(3-METHYL-1H-INDAZOL-6-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 1227911-51-4
• Molecular Formula: C₁₄H₁₉BN₂O₂
• Molecular Weight: 258.12386
• Mol File: 1227911-51-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole(1227911-51-4)
• EPA Substance Registry System: 3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole(1227911-51-4)

Safety Data

• Hazardous Substances Data: 1227911-51-4(Hazardous Substances Data)

Usage

General Description

3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is a chemical compound with the molecular formula C17H22BN2O2. It is a boron-containing indazole derivative with potential applications in organic synthesis and medicinal chemistry. 3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is known for its ability to act as a versatile building block for the preparation of various functionalized indazole derivatives. It contains a boron atom bonded to a dioxaborolane group, which makes it a valuable reagent for Suzuki-Miyaura cross-coupling reactions. Additionally, the indazole moiety in this compound has been found to exhibit interesting pharmacological properties, making it a potential candidate for the development of new drugs or bioactive molecules.

Upstream product

• 353282-88-9 1-(4-bromo-2-fluorophenyl)ethanol 
• 625446-22-2 4-bromo-2-fluoroacetophenone 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 7746-27-2 6-bromo-3-methyl-1 H-indazole 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1408085-20-0 2-(1-(4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one 
• 1300585-03-8 2-(1-(4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-phenyl-4H-chromen-4-one 
• 1300585-02-7 2-(1-(4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-phenyl-4H-chromen-4-one 
• 1227911-54-7 (3S,6R)-6-methyl-1-[2-(methylamino)-6-(3-methyl-1H-indazol-6-yl)-4-pyrimidinyl]-N-(phenylmethyl)-3-piperidinecarboxamide 
• 1227911-53-6 (3S,6R)-N-cyclohexyl-6-methyl-1-[2-(methylamino)-6-(3-methyl-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinecarboxamide 
• 1227911-52-5 (3S,6R)-6-methyl-1-[2-(methylamino)-6-(3-methyl-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-3-piperidinecarboxamide 

Relevant articles and documents

Cyclic Ureas

Amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

NOVEL KINASE MODULATORS

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.