1227929-85-2Relevant articles and documents
Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system
Shigenaga, Akira,Yamamoto, Jun,Hirakawa, Hiroko,Ogura, Keiji,Maeda, Nami,Morishita, Ko,Otaka, Akira
supporting information; experimental part, p. 2525 - 2528 (2010/06/16)
To develop a thiol-responsive DNA-releasing system, a thiol-responsive amino acid capable of inducing an amide bond cleavage in the presence of a thiol was developed. It was successfully combined with peptide nucleic acid (PNA), and thiol-induced release of DNA from the thiol-responsive PNA/DNA complex was observed.