1228006-83-4Relevant academic research and scientific papers
Microwave assisted one-pot synthesis of pyrrolo[2,1-b]thiazol-6-ones from α-Aroyl ketene-N,S-acetals
Mathew, Paulson,Prasidha,Asokan
experimental part, p. 430 - 435 (2010/06/16)
(Chemical Equation Presented) α-Aroyl ketene-N,S-acetals 3 prepared by the reaction of b-oxothioamides 1 with phenacyl bromides 2, underwent sequential cyclizations under microwave irradiation to afford pyrrolo[2,1-b]thiazol-6-ones 6 in good yields. A double cyclization takes place regioselectively in one pot and variety of functionalized pyrrolo[2,1-b]thiazol- 6-ones were prepared by this protocol. The mode of cyclization under microwave condition is different from conventional heating.
