1228017-20-6

Basic information

• Product Name: C₂₃H₁₄ClNO₄
• CAS NO: 1228017-20-6
• Molecular Weight: 403.821
• Mol File: 1228017-20-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₄ClNO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₄ClNO₄(1228017-20-6)
• EPA Substance Registry System: C₂₃H₁₄ClNO₄(1228017-20-6)

Safety Data

• Hazardous Substances Data: 1228017-20-6(Hazardous Substances Data)

Upstream product

• 3260-49-9 4,6-dihydroxybenzofuran-3(2H)-one 
• 1217-83-0 2-(4-chlorophenyl)-1H-indole-3-carbaldehyde 

Relevant articles and documents

Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of rapamycin: Hit to lead studies

A series of benzofuran-3-one indole phosphatidylinositol-3-kinases (PI3K) inhibitors identified via HTS has been prepared. The optimized inhibitors possess single digit nanomolar activity against p110α (PI3K-α), good pharmaceutical properties, selectivity versus p110γ (PI3K-γ), and tunable selectivity versus the mammalian target of rapamycin (mTOR). Modeling of compounds 9 and 32 in homology models of PI3K-α and mTOR supports the proposed rationale for selectivity. Compounds show activity in multiple cellular proliferation assays with signaling through the PI3K pathway confirmed via phospho-Akt inhibition in PC-3 cells.