1228024-50-7

Upstream product

• 1228024-12-1 N-[(3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-dicyclohexylacetamide 
• 1384106-78-8 (R,E)-N-((3aS,6aR)-2-benzylhexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)-2-methylpropane-2-sulfinamide 
• 1384106-80-2 (R)-N-((3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl)-2-methylpropane-2-sulfinamide 
• 1228029-76-2 (3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine 
• 52034-92-1 dicyclohexylacetic acid 

Downstream Products

• 1228024-51-8 2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide 
• 1228025-17-9 N-[(3aS,4S,6aR)-2-benzhydryloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-dicyclohexylacetamide 
• 1228025-90-8 2,2-dicyclohexyl-N-((3aS,4S,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)acetamide 
• 1228024-57-4 2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[2-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide 
• 1228024-53-0 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide 
• 1228024-52-9 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(2-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide 
• 1228024-60-9 2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[3-(trifluoromethoxy)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide 
• 1228024-58-5 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-methylbenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide 
• 1228024-61-0 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide 

Relevant academic research and scientific papers

Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca 2+ channel blockers with analgesic activity

A novel 4-aminocyclopentapyrrolidine series of N-type Ca2+ channel blockers have been discovered. Enantioselective synthesis of the 4-aminocyclopentapyrrolidines was enabled using N-tert-butyl sulfinamide chemistry. SAR studies demonstrate selectivity over L-type Ca2+ channels. N-type Ca2+ channel blockade was confirmed using electrophysiological recording techniques. Compound 25 is an N-type Ca 2+ channel blocker that produces antinociception in inflammatory and nociceptive pain models without exhibiting cardiovascular or motor liabilities.

NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS

The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.