1228093-49-9Relevant academic research and scientific papers
Synthesis of polyfluorinated benzofurans
Politanskaya, Larisa,Troshkova, Nadezhda,Tretyakov, Evgeny,Xi, Chanjuan
, (2019/09/18)
A simple and efficient approach to the synthesis of fluorinated benzofurans including the Sonogashira cross-coupling of o-iodophenols with terminal Ph- and n-Bu-acetylenes, followed by intramolecular cyclization, in good to excellent yields is reported.
Efficient and reliable iodination and o-Methylation of fluorinated phenols
Francke, Robert,Schnakenburg, Gregor,Waldvogel, Siegfried R.
experimental part, p. 2357 - 2362 (2010/07/04)
Fluorinated phenols and other electron-deficient phenolic substrates are efficiently and cleanly iodinated by an iodine/ iodide mixture employing alkaline conditions. This protocol turned out to be the most practical for the generation of such highly fluorinated iodophenols. For later application in coupling processes the protection of the phenolic hydroxy moiety is often required. Therefore, a practical iodination and subsequent methylation sequence was elaborated providing the highly fluorinated anisoles with good to excellent yields. The developed method is applicable for a broad scope of fluorinated phenols and analogues.
