1228093-50-2Relevant academic research and scientific papers
Efficient and reliable iodination and o-Methylation of fluorinated phenols
Francke, Robert,Schnakenburg, Gregor,Waldvogel, Siegfried R.
experimental part, p. 2357 - 2362 (2010/07/04)
Fluorinated phenols and other electron-deficient phenolic substrates are efficiently and cleanly iodinated by an iodine/ iodide mixture employing alkaline conditions. This protocol turned out to be the most practical for the generation of such highly fluorinated iodophenols. For later application in coupling processes the protection of the phenolic hydroxy moiety is often required. Therefore, a practical iodination and subsequent methylation sequence was elaborated providing the highly fluorinated anisoles with good to excellent yields. The developed method is applicable for a broad scope of fluorinated phenols and analogues.
Synthesis of highly fluorinated 2,2′-biphenols and 2,2′-bisanisoles
Francke, Robert,Schnakenburg, Gregor,Waldvogel, Siegfried R.
scheme or table, p. 4288 - 4291 (2010/12/18)
Figure Presented. Multiply fluorine-substituted iodo anisoles are efficiently coupled in an Ullmann-type reaction to provide the corresponding bisanisoles. The coupling is selective and even tolerates bromo moieties. Subsequent deprotection of hydroxy gro
