1228102-01-9

Usage

Uses

Used in Pharmaceutical Industry:
(3-(2-(3-(morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino))phenol is used as a potential therapeutic agent for various conditions due to its anticipated pharmacological properties. The presence of the phenol and amine groups suggests that (3-(2-(3-(morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino))phenol could interact with biological targets, making it a candidate for further research into its potential as an anticancer, antimicrobial, or antiviral agent.
Used in Drug Development Research:
In the field of drug development, (3-(2-(3-(morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino))phenol serves as a subject of investigation for its possible role in the creation of new medications. Its unique structure and the biological activities associated with similar compounds make it a promising candidate for exploring novel treatment options.
Further research and testing are essential to fully understand the pharmacological and biological properties of (3-(2-(3-(morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino))phenol, as well as to determine its safety and efficacy in various applications.

Upstream product

• 1228103-44-3 N-(3-(4-methoxybenzyloxy)phenyl)-2-(3-(morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-amine 

Relevant academic research and scientific papers

LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation

Wound healing generally induces an inflammatory response associated with tissue fibrosis in which activated macrophage and myofibroblast cells are primarily involved. Although this is known to be the underlying mechanism for scarring and various fibrotic pathologies, no effective intervention is currently available. We identified (3-(2-(3-(morpholinomethyl)phenyl)thieno[3,2- b]pyridin- 7-ylamino)phenol (LCB 03-0110), a thienopyridine derivative, as a potent inhibitor of discoidin domain receptor family tyrosine kinases and discovered that this compound strongly inhibits several tyrosine kinases, including the c-Src family, spleen tyrosine kinase, Bruton's tyrosine kinase, and vascular endothelial growth factor receptor 2, which are important for immune cell signaling and inflammatory reactions. LCB 03-0110 suppressed the proliferation and migration of primary dermal fibroblasts induced by transforming growth factor β1 and type I collagen, and this result correlated with the inhibition ability of the compound against enhanced expression of α-smooth muscle actin and activation of Akt1 and focal adhesion kinase. In J774A.1 macrophage cells activated by lipopolysaccharide LCB 03-0110 inhibited cell migration and nitric oxide, inducible nitric-oxide synthase, cyclooxygenase 2, and tumor necrosis factor-α synthesis. LCB 03-0110 applied topically to full excisional wounds on rabbit ears suppressed the accumulation of myofibroblast and macrophage cells in the healing wound and reduced hypertrophic scar formation after wound closing, without delaying the wound closing process. Taken together, the pharmacological activities of LCB 03-0110 suggest that it could be an effective agent for suppressing fibroinflammation by simultaneously targeting activated fibroblasts and macrophages. Copyright