1228115-29-4Relevant academic research and scientific papers
Regioselective synthesis of 3-benzazepinones and unexpected 5-bromo-3-benzazepinones
Zhang, Lei,Ye, Deju,Zhou, Yu,Liu, Guannan,Feng, Enguang,Jiang, Hualiang,Liu, Hong
experimental part, p. 3671 - 3677 (2010/07/13)
Figure presented A regioselective hydroamidation of 2-(1-alkynyl) phenylacetamides with Au(PPh3)Cl/AgSbF6 as the catalyst proceeded by a 7-endo-dig pathway to afford 3-benzazepinones. This method accommodates a broad range of alkyl and aryl alkynyl substitutes in moderate to high yields (63-91%). Moreover, unexpectedly, we also discovered a gold-mediated transformation from 2-(1-alkynyl)phenylacetamides to 5-bromo-3-benzazepinones, and AuBr3 was found to not only play an activation role but also act as a reactant in the reaction for the first time.
