1228150-44-4Relevant academic research and scientific papers
Rapid access of some trisubstituted imidazoles from benzil condensed with aldehydes and ammonium acetate catalyzed by L-cysteine
Roy,Rahman,Pramanick
, p. 153 - 159 (2013/02/25)
A simple highly versatile and efficient synthesis of 2,4,5- trisubstituted imidazole is achieved by three component cyclocondensation of benzil, substituted aromatic aldehyde and ammonium acetate by L-cysteine as organocatalyst under solvent free condition. The key advantages of this process are high yields, cost effectiveness catalyst, easy purification technique and above all environmentally benign.
Simple and efficient method for the synthesis of highly substituted imidazoles using zeolite-supported reagents
Sivakumar,Kathirvel,Lalitha
experimental part, p. 3018 - 3021 (2010/07/10)
Cu(II) nitrate impregnated zeolite has been used as an efficient supported reagent for an improved and rapid one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles in excellent yields. Condensation in the presence of supported reagents with operational simplicity, inexpensive reagents, high yield of products, and the use of non-toxic reagents makes this synthetic protocol, an attractive one.
