1228150-85-3Relevant academic research and scientific papers
FeCl3·6H2O as a Mild Catalyst for Nucleophilic Substitution of Symmetrical Bis(indoyl)methanes
Chantana, Chayamon,Jaratjaroonphong, Jaray
, p. 2312 - 2327 (2021)
In this paper, unsymmetrical bis(indolyl)methane (BIM) and 3-alkylindole derivatives are smoothly synthesized from symmetrical BIMs with a variety of nucleophiles including heteroaromatic/aromatic compounds, allylsilane and alkynylsilane. FeCl3·6H2O is found to be a mild and highly effective catalyst for this nucleophilic substitution reaction in which N-methyl-2-phenylindole behaves as a good leaving group in the Csp3-Csp2 bond cleavage reaction. The operational ease, nonexpensive and environmentally friendly catalyst, mild reaction conditions, broad functional group tolerance, and scalability of this reaction strategy are advantages of the present procedure.
CeCl3.7H2O-catalysed rapid synthesis of bis (indolyl) methanes under solvent-free conditions
Das, Biswanath,Kumar, Rathod Aravind,Aruna, Danavath,Kashanna, Jajula
experimental part, p. 295 - 296 (2011/12/05)
Cerium (III)-chloride heptahydrate (CeCl3.7H2O) catalyzes efficiently the electrophilic substitution reaction of indoles with aldehydes under solvent-free conditions to form the corresponding bis (indolyl) methanes at room temp. The
