1228171-75-2Relevant academic research and scientific papers
Thermodynamic equilibration in Pd(0)-catalyzed interconversion of highly constrained [2.1.2] bicyclic lactones: its mechanistic investigation
Han, Young Taek,Paek, Seung-Mann,Lee, Sujin,Jung, Jong-Wha,Jung, Jae-Kyung,Seo, Seung-Yong,Lee, Jeeyeon,Suh, Young-Ger
scheme or table, p. 2697 - 2699 (2010/06/19)
Mechanistic study on the stereoselective construction of [2.1.2] bicyclic lactone skeleton via Pd(0)-catalyzed intramolecular allylic alkylation was described. The observed excellent stereoselectivity is likely due to Pd(0)-catalyzed equilibration of highly strained [2.1.2] bicyclic lactone framework via π-σ-π isomerization of π-allylpalladium complex. An efficient synthetic route to allylic carbonate as a requisite cyclization precursor has also been developed by employing a sequence of ring-closing metathesis, followed by epoxidation/desilylation of the resulting substituted oxasilepene intermediate.
