1228231-62-6Relevant articles and documents
N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer
Liu, Yang,Xia, Yi,Fan, Yuting,Maggiani, Alain,Rocchi, Palma,Qu, Fanqi,Iovanna, Juan L.,Peng, Ling
supporting information; experimental part, p. 2503 - 2507 (2010/07/16)
Novel N-aryltriazole nucleosides were synthesized via Cu-mediated C-N cross-coupling reaction starting with 3-aminotriazole ribonucleoside and various boronic acids. Two of them exhibited potent apoptosis-related antiproliferative activity against the drug-resistant pancreatic cancer cell line MiaPaCa-2, with an increased potency compared to gemcitabine, the reference treatment for pancreatic cancer. A preliminary SAR study suggests that the appended N-aryl moiety and the substituent at its para-position, as well as the ribose sugar component, contribute considerably to the observed antiproliferative activity.