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1228246-10-3

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1228246-10-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1228246-10-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,2,4 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1228246-10:
(9*1)+(8*2)+(7*2)+(6*8)+(5*2)+(4*4)+(3*6)+(2*1)+(1*0)=133
133 % 10 = 3
So 1228246-10-3 is a valid CAS Registry Number.

1228246-10-3Downstream Products

1228246-10-3Relevant academic research and scientific papers

2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: Optimization of human microsomal stability

Verheijen, Jeroen C.,Richard, David J.,Curran, Kevin,Kaplan, Joshua,Yu, Ker,Zask, Arie

scheme or table, p. 2648 - 2653 (2010/07/05)

Isosteric replacement of one of the 3,5-ethylene-bridged morpholines in 2-arylureidophenyl-4,6-di(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines led to significant improvements in human microsomal stability. 3-R-Me-morpholine and tetrahydropyran were identified as preferred isosteres for the bridged morpholine. Combination of tetrahydropyran substitution with an N-Me-piperazinophenylureido group led to 27, that selectively suppressed mTOR biomarkers in vivo and possessed excellent efficacy in a murine xenograft model.

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