1228255-74-0

Basic information

• Product Name: C₂₉H₃₄NO₅P
• CAS NO: 1228255-74-0
• Molecular Weight: 507.566
• Mol File: 1228255-74-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₄NO₅P(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₄NO₅P(1228255-74-0)
• EPA Substance Registry System: C₂₉H₃₄NO₅P(1228255-74-0)

Safety Data

• Hazardous Substances Data: 1228255-74-0(Hazardous Substances Data)

Upstream product

• 207125-24-4 1-chlorotetrahydro-(1S,3aS)-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphole 
• 110675-04-2 3<(4,4'-dimethoxytrityl)oxy>propan-1-ol 

Relevant articles and documents

DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS

The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula (1) are produced in a stereocontrolled manner.