1228275-70-4Relevant academic research and scientific papers
Ring-construction/stereoselective functionalization cascade: Total synthesis of pachastrissamine (Jaspine B) through palladium-catalyzed bis-cyclization of propargyl chlorides and carbonates
Inuki, Shinsuke,Yoshimitsu, Yuji,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
experimental part, p. 3831 - 3842 (2010/09/03)
Figure presented Palladium(0)-catalyzed cyclization of bromoallenes, propargyl chlorides, and carbonates bearing hydroxy and benzamide groups as internal nucleophiles stereoselectively provides functionalized tetrahydrofuran. Cyclization reactivity is dependent on the relative configuration of the benzamide and leaving groups, and on the nature of the leaving groups. This bis-cyclization was used as the key step in a short total synthesis of pachastrissamine, which is a biologically active marine natural product.
Ring-construction/stereoselective functionalization cascade: Total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of bromoallenes
Lnuki, Shinsuke,Yoshimitsu, Yuji,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
supporting information; experimental part, p. 4478 - 4481 (2009/12/24)
Palladium(0)-catalyzed cyclization of bromoallenes bearing hydroxyl and benzamide groups as internal nucleophiles stereoselectively provides functlonallzed tetrahydrofuran. With this bis-cyclizatlon as the key step, a short total synthesis of pachastrissa
