1228299-91-9Relevant academic research and scientific papers
Isothiourea-catalysed asymmetric C-acylation of silyl ketene acetals
Woods, Philip A.,Morrill, Louis C.,Bragg, Ryan A.,Smith, Andrew D.
, p. 11060 - 11067 (2011/10/19)
Screening of a range of chiral isothioureas and acyl donors to promote the asymmetric C-acylation of silyl ketene acetals indicates that C(2)-aryl-dihydropyrimidobenzothiazole-derived isothioureas and propionic anhydride give optimal reactivity and enantioselectivity in this process. Under optimised conditions 3-acyl-3-aryl or 3-acyl-3-alkylfuranones are prepared in good yields and moderate to excellent enantioselectivities (up to 98 % ee; ee=enantiomeric excess).
Isothiourea-mediated stereoselective C-acylation of silyl ketene acetals
Woods, Philip A.,Morrill, Louis C.,Lebl, Tomas,Slawin, Alexandra M. Z.,Bragg, Ryan A.,Smith, Andrew D.
supporting information; experimental part, p. 2660 - 2663 (2010/08/21)
Isothiourea DHPB promotes the diastereoselective C-acylation of silyl ketene acetals with anhydrides or benzoyl fluoride, giving 3-acyl-3-aryl or 3-acyl-3-alkylfuranones in excellent yields and stereoselectivities (up to 99:1 dr).
