122830-65-3Relevant academic research and scientific papers
Penta- and hexadienoic acid derivatives: A novel series of 5-lipoxygenase inhibitors
Malleron,Roussel,Gueremy,Ponsinet,Robin,Terlain,Tissieres
, p. 2744 - 2749 (2007/10/02)
The synthesis of a series of pentadienoic ajnd hexadienoic acid derivatives is reported. These compounds were tested as inhibitors of 5-lipoxygenase (5 LO) and cyclooxygenase (CO) in vitro and as inhibitors of arachidonic acid (AA) induced ear edema in mi
Alkadiene derivatives, their preparation, and pharmaceutical compositions containing them
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, (2008/06/13)
Substituted alkadienes of the formula: STR1 in which R1 is hydroxy or acetoxy, R2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, and R3 is alkylthio or alkoxy and R4 is naphthoyl or optionally substituted benzoyl, or R3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio, or R3 and R4 form, with the carbon atom to which they are attached, a ring-system of formula: STR2 in which R5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.
