122833-59-4Relevant articles and documents
A Catalytic Enantioselective Reaction Using a C2-Symmetric Disulfonamide as a Chiral Ligand: Alkylation of Aldehydes Catalyzed by Disulfonamide-Ti(O-i-Pr)4-Dialkyl Zinc System
Takahashi, Hideyo,Kawakita, Takashi,Ohno, Masaji,Yoshioka, Masato,Kobayashi, Susumu
, p. 5691 - 5700 (1992)
Excellent enantioselective alkylation of aldehydes with dialkylzinc has been developed.This methodology is based on the concept of modifying the Lewis acid with a C2-symmetric, electron-withdrawing disulfonamide.The chiral Lewis acid catalysts used in the present study are the titanium complexes, prepared in-situ from disulfonamide and Ti(O-i-Pr)4.Key Words: Chiral disulfonamide; chiral titanium complex; enantioselective alkylation; dialkyl zinc; catalytic reaction