1228359-05-4Relevant academic research and scientific papers
Synthesis of new β-1-C-alkylated imino-l-iditols: A comparative study of their activity as β-glucocerebrosidase inhibitors
Sch?nemann, Wojciech,Gallienne, Estelle,Compain, Philippe,Ikeda, Kyoko,Asano, Naoki,Martin, Olivier R.
, p. 2645 - 2650 (2010)
A short synthesis of new β-1-C-alkyl-1,5-dideoxy-1,5-imino-l-iditols by means of the diastereoselective addition of Grignard reagents onto a glucopyranosylamine is described. These compounds were evaluated as β-glucocerebrosidase inhibitors and their activity was compared with that of related iminosugar derivatives in the d-gluco and d-xylo series. The results allowed us to conclude on the influence of the hydroxymethyl moiety and of the piperidine-ring conformation on the inhibitory activity.
