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(2R,4S)-2-trifluoromethyloxazolidine-4-carboxylic acid benzyl ester is a chiral building block with a molecular formula of C11H12F3NO3. It is an ester derivative of (2R,4S)-2-trifluoromethyloxazolidine-4-carboxylic acid, which is commonly used in the synthesis of pharmaceuticals and agrochemicals. The benzyl ester group in (2R,4S)-2-trifluoromethyloxazolidine-4-carboxylic acid benzyl ester enhances its stability and solubility, making it a valuable intermediate in organic synthesis. Due to its stereochemical properties, it is often employed in asymmetric synthesis and medicinal chemistry. Careful handling and adherence to proper safety precautions are necessary due to its acidity and potential reactivity.

1228376-93-9

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1228376-93-9 Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
(2R,4S)-2-trifluoromethyloxazolidine-4-carboxylic acid benzyl ester is used as a chiral building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which is crucial for the development of effective and safe drugs and agrochemicals.
Used in Asymmetric Synthesis:
(2R,4S)-2-trifluoromethyloxazolidine-4-carboxylic acid benzyl ester is used as a key intermediate in asymmetric synthesis. Its stereochemistry enables the selective formation of specific enantiomers, which is essential for producing biologically active compounds with desired properties.
Used in Medicinal Chemistry:
(2R,4S)-2-trifluoromethyloxazolidine-4-carboxylic acid benzyl ester is used as a versatile intermediate in medicinal chemistry. Its stability and solubility, along with its stereochemical properties, make it suitable for the development of novel therapeutic agents and drug candidates.

Check Digit Verification of cas no

The CAS Registry Mumber 1228376-93-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,3,7 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1228376-93:
(9*1)+(8*2)+(7*2)+(6*8)+(5*3)+(4*7)+(3*6)+(2*9)+(1*3)=169
169 % 10 = 9
So 1228376-93-9 is a valid CAS Registry Number.

1228376-93-9Downstream Products

1228376-93-9Relevant academic research and scientific papers

Synthesis of 2-trifluoromethyl-1,3-oxazolidines as hydrolytically stable pseudoprolines

Chaume, Gregory,Barbeau, Olivier,Lesot, Philippe,Brigaud, Thierry

, p. 4135 - 4145 (2010)

Trifluoromethyl group containing oxazolidines (Fox) are conveniently synthesized by condensation of serine esters with trifluoroacetaldehyde hemiacetal or trifluoroacetone. These oxazolidines can undergo N-acylation and amidification reactions and are com

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