122839-50-3

Upstream product

• 82317-77-9 methyl (R)-2-acetamido-3-(4-(trifluoromethyl)phenyl)propanoate 
• 82337-58-4 2-acetamido-3-(4-(trifluoromethyl)phenyl)propanoic acid 
• 143051-58-5 (R)-4-trifluoromethyl-N-benzoyl-phenylalanine 
• 143051-49-4 (Z)-2-Benzoylamino-3-(4-trifluoromethyl-phenyl)-acrylic acid 
• 114872-59-2 diethyl 2-acetamido-2-<<4-(trifluoromethyl)phenyl>methyl>malonate 
• 82317-73-5 2-Acetylamino-3-(4-trifluoromethyl-phenyl)-propionic acid methyl ester 

Downstream Products

• 82317-83-7 (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid 

Relevant academic research and scientific papers

SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

It is an object of the present invention to provide a substituted propanamide derivative or a pharmacologically acceptable salt thereof that is useful as a prophylactic or therapeutic agent for a bone metabolic disease. The present invention relates to a pharmaceutical composition comprising a compound having General Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 represents a C6-C10 aryl group that may be substituted by a group selected from Substituent Group α, for example; R2 represents a C6-C10aryl group that may be substituted by a group selected from Substituent Group α, for example; and X represents a hydroxyl group or a C1-C6 alkoxy group, for example].

UNUSUAL AMINO ACIDS II. Asymmetric Synthesis of Fluorine Containing Phenylalanines

Few (Z)-α-N-benzoylamino-β-(fluorophenyl)-acrylic acids and their esters were prepared by known procedures and hydrogenated to the corresponding optically active α-benzoyl-β-(fluorophenyl)-alanine derivatives with optical yields up to 90percent using the