122841-09-2Relevant articles and documents
3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: A novel class of factor XIIIa inhibitors
Leung-Toung, Regis,Tam, Tim F.,Wodzinska, Jolanta M.,Zhao, Yanqing,Lowrie, Jayme,Simpson, Craig D.,Karimian, Khashayar,Spino, Michael
, p. 2266 - 2269 (2005)
A new class of selective FXIIIa inhibitors with a bicyclic [1,2,4]-thiadiazole pharmacophore is described. At 160 μM, compound 8 caused 50% reduction in fibrin γ-chain crosslinking and suppressed the polymerization of a?chains in platelet-depleted human p