122841-10-5 Usage
Biological Activity
cefoselis is a widely used antibiotic of β-lactam [1].cefoselis has a large antibacterial spectrum against gram positive bacterium. it is a 4th generation of cephalosporin. cefoselis has some side effects, such as inducing seizures and convulsion in elder and renal failure patients. through testing the dialysate and blood samples by hplc, it shows that cefoselis appears in the striatal dialysate samples does-dependently and disappears rapidly from the extracellular fluid. in renal failure rats, the elimination half-lives of cefoselis are prolonged. it may be one factor of the seizures caused by cefoselis. in addition, administration of cefoselis into the hippocampus causes highly increase of extracellular glutamate and slightly increase of gaba, suggesting that cefoselis induces seizures through blocking the gaba receptors [1].
references
[1] ohtaki k, matsubara k, fujimaru s, shimizu k, awaya t, suno m, chiba k, hayase n, shiono h. cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. j neural transm. 2004 dec;111(12):1523-35.
Check Digit Verification of cas no
The CAS Registry Mumber 122841-10-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,8,4 and 1 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 122841-10:
(8*1)+(7*2)+(6*2)+(5*8)+(4*4)+(3*1)+(2*1)+(1*0)=95
95 % 10 = 5
So 122841-10-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H22N8O6S2/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28/h2-3,8,13,17,20,28H,4-7H2,1H3,(H4,21,22,23,29,31,32)/b24-12+/t13-,17-/m1/s1
122841-10-5Relevant articles and documents
NOVEL INTERMEDIATES FOR SYNTHESIS OF CEPHALOSPORINS AND PROCESS FOR PREPARATION OF SUCH INTERMEDIATES
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Page 32, (2008/06/13)
A novel 4-halo-2-oxyimino-3-oxo butyric acid-N, N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics, wherein X is chlorine or bromine; R is hydrogen, C1-4 alkyl group, an easily removable hydroxyl protective group, -CH2COOR5, or -C(CH3)2COOR5, wherein R5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV1), wherein X, R and R5 are as defined above, with N, N-dimethylformiminium chloride chlorosulphate of formula (VII), in an organic solvent at a temperature ranging from -30 °C to -15 °C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.
