1228440-72-9

Upstream product

• 1228440-67-2 2-{[4-bromoacetyl-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester 
• 1228440-76-3 2-[(4-{[methoxy(methyl)amino]carbonyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester 
• 1228440-66-1 2-{[4-acetyl-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester 
• 1228440-58-1 2-[(4-{[(4'-fluorobiphenyl-4-yl)oxy]acetyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester 
• 1228440-73-0 2-(1-tert-butoxycarbonyl-1-methyl-ethylsulfanyl)-thiazole-4-carboxylic acid methyl ester 
• 1228440-56-9 2-{[4-(chloroacetyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester 
• 324-94-7 4'-fluoro-biphenyl-4-ol 
• 886527-12-4 2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazole-4-carboxylic acid 
• 1228440-59-2 2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 

Relevant academic research and scientific papers

CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF

A compound represented by the formula (I) wherein R1 and R2 are each a hydrogen atom, an alkyl group and the like, R3 is a hydrogen atom, an alkyl group and the like, R4 is a hydrogen atom, an alkyl group and the like, m is an integer of 0 to 3, X is a bond, an oxygen atom or a sulfur atom, Y is a carbonyl group, a hydroxymethylene group and the like, and Z is a halogen atom, an alkyl group, an aryl group, a heteroaryl group and the like, or a pharmaceutically acceptable salt thereof has a superior PPARα agonist action and a lipid-lowering action, and is useful as a prophylactic or therapeutic drug for hyperlipidemia and the like.