1228441-07-3Relevant academic research and scientific papers
The first F-ring modified ciguatoxin analogue showing significant toxicity
Ishihara, Yuuki,Lee, Nayoung,Oshiro, Naomasa,Matsuoka, Shigeru,Yamashita, Shuji,Inoue, Masayuki,Hirama, Masahiro
supporting information; experimental part, p. 2968 - 2970 (2010/08/04)
Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are potent neurotoxic polycyclic ethers. We report herein the total synthesis of a 10-membered F-ring analogue of 51-hydroxyCTX3C, which constitutes the first example of an F-ring modified ciguatoxin that exhibits potent cytotoxicity as well as mouse acute toxicity. The Royal Society of Chemistry 2010.
