1228443-29-5Relevant academic research and scientific papers
Highly Selective Biocatalytic Transesterification Reactions on Aryl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoates
Kumar, Gaurav,Dhawan, Ashish,Singh, Brajendra K.,Sharma, Nawal K.,Sharma, Sunil K.,Prasad, Ashok K.,Van Der Eycken, Erik V.,Len, Christophe,Watterson, Arthur C.,Parmar, Virinder S.
, p. 919 - 929 (2015)
Acid anhydrides have been used to carry out the regioselective acylation of primary hydroxyl group in benzyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate and 4-fluorobenzyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate and deacylation of their diesters in the presence of Lipozyme TL IM in diisopropyl ether. Amongst different acid anhydrides used, butanoic anhydride was found to be the best acylating agent as compared to others. Both acylation and deacylation reactions were highly selective and efficient yielding exclusively the monoacylated products in 70-88 % yields.
Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds
Malhotra, Shashwat,Calderon, Marcelo,Prasad, Ashok K.,Parmar, Virinder S.,Haag, Rainer
experimental part, p. 2228 - 2237 (2010/07/04)
In the present work, we have developed a highly efficient temperature-dependent chemo-enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri-glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert-butoxycarbonyl)acetate (Boc-gly-Ph-pNO2) (2) as the acylating agent. This methodology offers efficient and controlled loading of amino acid (glycine) on polyhydroxy compounds.
