1228445-38-2 Usage
Uses
Pyrintegrin enhances the survival of Human embryonic stem cells (hESC).
Biological Activity
pyrintegrin, a 2,4-disubstituted pyrimidine, is a novel small-molecule inhibitor of bmp signaling which previously found to promote human embryonic stem cells survival [1].bone morphogenetic proteins (bmps) are members of the tgf-β superfamily of secreted signaling molecules with important roles in many biological contexts. bmps could bind to specificserine/threonine kinase receptors and transduce the signal to the nucleus through smad proteins [2].
in vitro
pyrintegrin induced differentiation of hadscs into adipogenic‐like cells in vitro. pyrintegrin drug treatment can accelerate adipocyte differentiation and augment lipid accumulation, adiponectin and fatty acid secretion in adipogenic medium differentiated human adipose derived stem cells [1]. pyrimidine (2 μm) enhanced the survival of hesc more than 30-fold after trypsin-mediated dissociation. pyrimidine increased integrin-dependent attachment of hesc to extracellular matrices without significantly impacting cell proliferation. pyrintegrin increased the binding of the activated β1 integrin-specific antibody huts-21 and enhanced the phosphorylation of multiple growth factor receptors and their downstream kinases, pi3k and mapk [3].
in vivo
pyrintegrin promoted proliferation and differentiation of adipose precursor cells depending on their microenvironment. pyrintegrin increased the number of preadipocytes and the rate of adipocyte differentiation, resulting in enhanced de novo adipogenesis [1].
references
[1] shah b s. pyrintegrin induced adipogenesis: biology[d]. columbia university, 2012.[2] von bubnoff a, cho k w y. intracellular bmp signaling regulation in vertebrates: pathway or network[j]. developmental biology, 2001, 239(1): 1-14.[3] xu y, zhu x, hahm h s, et al. revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules[j]. proceedings of the national academy of sciences, 2010, 107(18): 8129-8134.
Check Digit Verification of cas no
The CAS Registry Mumber 1228445-38-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,4,4 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1228445-38:
(9*1)+(8*2)+(7*2)+(6*8)+(5*4)+(4*4)+(3*5)+(2*3)+(1*8)=152
152 % 10 = 2
So 1228445-38-2 is a valid CAS Registry Number.
1228445-38-2Relevant articles and documents
INDUCTION OF PLURIPOTENT CELLS
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, (2012/10/23)
The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>
