1228447-67-3Relevant academic research and scientific papers
Enhancement of antiproliferative activity by molecular simplification of catalpol
García, Celina,León, Leticia G.,Pungitore, Carlos R.,Ríos-Luci, Carla,Daranas, Antonio H.,Montero, Juan C.,Pandiella, Atanasio,Tonn, Carlos E.,Martín, Víctor S.,Padrón, José M.
, p. 2515 - 2523 (2010)
Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed α-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38-1.86 μM. Cell cycle studies for these compounds showed the induction of cell cycle arrest at the G1 phase. This result was consistent with a decrease in the expression of cyclin D1. Damaged cells underwent apoptosis as indicated by specific Annexin V staining.
