1228454-86-1Relevant articles and documents
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
Brnardic, Edward J.,Fraley, Mark E.,Garbaccio, Robert M.,Layton, Mark E.,Sanders, John M.,Culberson, Chris,Jacobson, Marlene A.,Magliaro, Brian C.,Hutson, Pete H.,O'Brien, Julie A.,Huszar, Sarah L.,Uslaner, Jason M.,Fillgrove, Kerry L.,Tang, Cuyue,Kuo, Yuhsin,Sur, Sylvie M.,Hartman, George D.
scheme or table, p. 3129 - 3133 (2010/07/20)
Hit to lead optimization of (5R)-5-hexyl-3-phenyl-1,3-oxazolidin-2-one as a positive allosteric modulator of mGluR2 is described. Improvements in potency and metabolic stability were achieved through SAR on both ends of the oxazolidinone. An optimized lea
