1228459-59-3Relevant academic research and scientific papers
Formal total syntheses of (+)-prelaureatin and (+)-laurallene by diastereoselective brook rearrangement-mediated [3 + 4] annulation
Sasaki, Michiko,Oyamada, Kazuhisa,Takeda, Kei
supporting information; experimental part, p. 3941 - 3943 (2010/08/06)
Figure presented The formal syntheses of (+)-prelaureatin (1) and (+)-laurallene (2), halogenated eight-membered-ring ethers, are described. The key step of our strategy relies on diastereoselective construction of a trans-α,α′-disubstituted oxocene structure through a Brook rearrangement-mediated [3 + 4] annulation with acryloylsilane 9 and 6-oxa-2-cycloheptenone derivative 22′.
