1228504-90-2Relevant academic research and scientific papers
Synergistic iron-and-amine catalysis in carbocyclizations
Praveen, Chandrasekaran,Levêque, Sabine,Vitale, Maxime R.,Michelet, Véronique,Ratovelomanana-Vidal, Virginie
, p. 1334 - 1338 (2014/06/09)
The fruitful merger of iron catalysis to amine catalysis was successfully applied in the direct intramolecular addition of aldehydes to non-activated alkynes. Accordingly, the carbocyclizations of a range of formyl-alkynes afforded the corresponding cyclo
Copper(i)-amine metallo-organocatalyzed synthesis of carbo- and heterocyclic systems
Montaignac, Benjamin,Oestlund, Victor,Vitale, Maxime R.,Ratovelomanana-Vidal, Virgnie,Michelet, Veronique
supporting information; experimental part, p. 2300 - 2306 (2012/04/10)
The efficient and atom economical synthesis of 5-membered cyclic structures has been achieved through the combination of amino catalysis and metal catalysis. The discovery of a novel metallo-organocatalytic system merging the use of a catalytic copper(i)
Cooperative copper(I) and primary amine catalyzed room-temperature carbocyclization of formyl alkynes
Montaignac, Benjamin,Vitale, Maxime R.,Ratovelomanana-Vidal, Virginie,Michelet, Veronique
supporting information; experimental part, p. 3723 - 3727 (2011/09/12)
An efficient CuI/amine catalytic system is described for the carbocyclization of α-disubstituted formylalkynes at room temperature. Merging aminocatalysis to the copper(I)-catalyzed activation of alkynes led to clean carbocyclization of a wide range of functionalized substrates under mild conditions. This novel cooperative catalytic system allowed the formation of a variety of carbo- and heterocycles, including pyrrolidines, in good to excellent yields. Mechanistic aspects of this process are also discussed. Copyright
InCl3/CyNH2 cocatalyzed carbocyclization reaction: An entry to α-disubstituted exo -methylene cyclopentanes
Montaignac, Benjamin,Vitale, Maxime R.,Ratovelomanana-Vidal, Virginie,Michelet, Veronique
supporting information; experimental part, p. 8322 - 8325 (2011/02/28)
An efficient and cheap synthetic approach to functionalized exo-methylene cyclopentanes has been developed from α-disubstituted formyl-alkynes by merging amine catalysis with the indium activation of alkynes. We uncovered the crucial role of the amine cocatalyst and the development of a new cooperative catalytic system allowed the cyclization of a broad range of substrates. A mechanistic study was realized in order to rationalize the determining influence of the amine cocatalyst.
Combined InCl3- and amine-catalyzed intramolecular addition of α-disubstituted aldehydes onto unactivated alkynes
Montaignac, Benjamin,Vitale, Maxime R.,Michelet, Veronique,Ratovelomanana-Vidal, Virginie
supporting information; experimental part, p. 2582 - 2585 (2010/08/04)
The combination of enamine-type catalysis to the indium-catalyzed activation of alkynes allows the efficient preparation of functionalized cyclopentanes bearing a quaternary stereogenic center. A broad range of formylalkynyl derivatives has been prepared.
