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1228530-96-8

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  • 1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptan-2-one 1R,4S,6R)-4-(HYDROXYMETHYL)-3-AZABICYCLO[4.1.0]HEPTAN-2-ONE

    Cas No: 1228530-96-8

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1228530-96-8 Usage

General Description

The chemical "(1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptan-2-one" is a bicyclic compound containing a ketone group and a hydroxymethyl group. It has a molecular structure that includes a six-membered ring fused to a four-membered ring, with an oxygen atom attached to the carbon at position 2 of the smaller ring. 1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptan-2-one is a derivative of the natural product tropane, and it exhibits potential pharmacological activity due to its stereochemical arrangement and functional groups. Its unique structure makes it a valuable chemical intermediate in the synthesis of bioactive compounds, and it has potential applications in medicinal and synthetic organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1228530-96-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,5,3 and 0 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1228530-96:
(9*1)+(8*2)+(7*2)+(6*8)+(5*5)+(4*3)+(3*0)+(2*9)+(1*6)=148
148 % 10 = 8
So 1228530-96-8 is a valid CAS Registry Number.

1228530-96-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (1R,4S,6R)-4-(Hydroxymethyl)-3-azabicyclo[4.1.0]heptan-2-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:1228530-96-8 SDS

1228530-96-8Downstream Products

1228530-96-8Relevant articles and documents

An efficient scalable route for the synthesis of enantiomerically pure tert -butyl-(1 R,4 S,6 R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate

Maton, William M.,Stazi, Federica,Manzo, Angelo Maria,Pachera, Roberta,Ribecai, Arianna,Stabile, Paolo,Perboni, Alcide,Giubellina, Nicola,Bravo, Fernando,Castoldi, Damiano,Provera, Stefano,Turco, Lucilla,Bryant, Simon,Westerduin, Pieter,Profeta, Roberto,Nalin, Arnaldo,Miserazzi, Emanuele,Spada, Simone,Mingardi, Anna,Mattioli, Mario,Andreotti, Daniele

, p. 1239 - 1247 (2010)

An efficient scalable route to synthesize the enantiomerically pure tert-butyl-(1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3- carboxylate is described. Compared to the original routes, significant improvements were made by using an innovative approach starting from commercially available chiral lactone. In this approach, one of the key steps described is an elegant epimerization/hydrolysis of the undesired diastereoisomer avoiding tedious purification. The chemistry has been scaled up to produce kilogram amounts of tert-butyl-(1R,4S,6R)-4-(hydroxymethyl)-3- azabicyclo[4.1.0]heptane-3-carboxylate in 43% yield over nine chemical transformations.

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