1228549-96-9

Basic information

• Product Name: (2R)-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE
• Synonyms: (2R)-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE;(2R)-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE HCl salt
• CAS NO: 1228549-96-9
• Molecular Formula: C11H12F3N
• Molecular Weight: 215.2148896
• Mol File: 1228549-96-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 254.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.179±0.06 g/cm3(Predicted)
• PKA: 9.33±0.10(Predicted)
• CAS DataBase Reference: (2R)-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE(1228549-96-9)
• EPA Substance Registry System: (2R)-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE(1228549-96-9)

Safety Data

• Hazardous Substances Data: 1228549-96-9(Hazardous Substances Data)

Usage

General Description

(2R)-2-[4-(trifluoromethyl)phenyl]pyrrolidine is a chemical compound with the molecular formula C11H12F3N. It is a pyrrolidine derivative that contains a trifluoromethyl group attached to a phenyl ring. (2R)-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE is a chiral molecule, meaning it has a non-superimposable mirror image, and the (2R) designation indicates its stereochemistry. The trifluoromethyl group in this compound can impart unique chemical and physical properties, making it useful in the development of pharmaceuticals and agrochemicals. Its structure and properties contribute to its potential use as a building block in organic synthesis for the creation of new compounds.

Upstream product

• 123-75-1 pyrrolidine 
• 2786-01-8 (4-trifluoromethylphenyl)lithium 
• 72216-08-1 2-(4-(trifluoromethyl)phenyl)-1-pyrroline 

Relevant articles and documents

Enantioselective Synthesis of 2-Substituted Pyrrolidines via Intramolecular Reductive Amination

Catalyzed by the complex generated in situ from iridium and the chiral ferrocene ligand, tert -butyl (4-oxo-4-arylbutyl)carbamate substrates were deprotected and then reductively cyclised to form 2-substituted arylpyrrolidines in a one-pot manner, in which the intramolecular reductive amination was the key step. A range of chiral 2-substituted arylpyrrolidines were synthesised in up to 98percent yield and 92percent ee.

Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis

(Chemical Equation Presented) A series of meta- and para-substituted 2-arylpyrrolidines were synthesized and examined for their ability to catalyze an aqueous aldol reaction under buffered conditions. Kinetic analysis of arylpyrrolidine-catalyzed reactions displayed a linear Hammett correlation with ρ = 1.14 (R2 = 0.996), indicating that the reaction is accelerated by electron-withdrawing aryl rings. These results show promise for the development of a synthetically viable aqueous organocatalyst.