1228550-68-2Relevant articles and documents
New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents
Ancizu, Saioa,Moreno, Elsa,Solano, Beatriz,Villar, Raquel,Burguete, Asunción,Torres, Enrique,Pérez-Silanes, Silvia,Aldana, Ignacio,Monge, Antonio
experimental part, p. 2713 - 2719 (2010/06/14)
Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, Rifampin (RIF).