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1228553-27-2

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1228553-27-2 Usage

General Description

The chemical (3R)-2,3-Dihydrobenzo[b]furan-3-ylamine is a compound with the molecular formula C10H11NO. It is a derivative of benzo[b]furan, a heterocyclic compound containing both benzene and furan rings. The (3R) in its name indicates the stereochemistry of the molecule, specifically that the amine group is attached to the third carbon atom in a specific orientation. This chemical may have various potential applications in pharmaceuticals, agrochemicals, and materials science due to its unique structure and properties. Its synthesis and further research may reveal its potential use in the development of new drugs or materials for specific applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1228553-27-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,5,5 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1228553-27:
(9*1)+(8*2)+(7*2)+(6*8)+(5*5)+(4*5)+(3*3)+(2*2)+(1*7)=152
152 % 10 = 2
So 1228553-27-2 is a valid CAS Registry Number.

1228553-27-2Downstream Products

1228553-27-2Relevant articles and documents

ISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

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Page/Page column 174-176, (2021/02/12)

The present invention relates to a compound suitable for use as a kinase inhibitor

Titania-promoted carboxylic acid alkylations of alkenes and cascade addition-cyclizations

Manley, David W.,McBurney, Roy T.,Miller, Phillip,Walton, John C.,Mills, Andrew,O'Rourke, Christopher

, p. 1386 - 1398 (2014/03/21)

Photochemical reactions employing TiO2 and carboxylic acids under dry anaerobic conditions led to several types of C-C bond-forming processes with electron-deficient alkenes. The efficiency of alkylation varied appreciably with substituents in the carboxylic acids. The reactions of aryloxyacetic acids with maleimides resulted in a cascade process in which a pyrrolochromene derivative accompanied the alkylated succinimide. The selectivity for one or other of these products could be tuned to some extent by employing the photoredox catalyst under different conditions. Aryloxyacetic acids adapted for intramolecular ring closures by inclusion of 2-alkenyl, 2-aryl, or 2-oximinyl functionality reacted rather poorly. Profiles of reactant consumption and product formation for these systems were obtained by an in situ NMR monitoring technique. An array of different catalyst forms were tested for efficiency and ease of use. The proposed mechanism, involving hole capture at the TiO2 surface by the carboxylates followed by CO2 loss, was supported by EPR spectroscopic evidence of the intermediates. Deuterium labeling indicated that the titania likely donates protons from surface hydroxyl groups as well as supplying electrons and holes, thus acting as both a catalyst and a reaction partner.

Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans and its application to the formal total synthesis of (-)-quinocarcinamide

Chiba, Hiroaki,Sakai, Yuki,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki

supporting information, p. 6273 - 6276 (2013/01/14)

An unusual Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans is described. The fused tricyclic ring system is the key structural element for this reaction as it restricts C-N bond rotation and/or destabilizes the benzofuran ring. We achieved the formal total synthesis of (-)-quinocarcinamide using a combination of this reaction and the Au(I)-catalyzed 6-endo-dig hydroamination of an alkyne.

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