1228556-71-5

Basic information

• Product Name: (R)-4-broMo-2,3-dihydro-1H-inden-1-aMine-HCl
• Synonyms: (R)-4-broMo-2,3-dihydro-1H-inden-1-aMine-HCl;(R)-4-BroMo-2,3-dihydro-1H-inden-1-aMine hydrochloride;(1R)-4-broMo-2,3-dihydro-1H-inden-1-aMine;(R)-4-BROMO-2,3-DIHYDRO-1H-INDEN-1-AMINE
• CAS NO: 1228556-71-5
• Molecular Formula: C9H11BrClN
• Molecular Weight: 248.54734
• Mol File: 1228556-71-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-4-broMo-2,3-dihydro-1H-inden-1-aMine-HCl(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-broMo-2,3-dihydro-1H-inden-1-aMine-HCl(1228556-71-5)
• EPA Substance Registry System: (R)-4-broMo-2,3-dihydro-1H-inden-1-aMine-HCl(1228556-71-5)

Safety Data

• Hazardous Substances Data: 1228556-71-5(Hazardous Substances Data)

Usage

General Description

(R)-4-bromo-2,3-dihydro-1H-inden-1-amine hydrochloride, also known as "Rolipram," is a chemical compound that belongs to the class of indole derivatives. It is a selective phosphodiesterase-4 (PDE4) inhibitor, which means it inhibits the enzyme phosphodiesterase-4 and can potentially be used in the treatment of various inflammatory and neurological diseases. (R)-4-broMo-2,3-dihydro-1H-inden-1-aMine-HCl has been studied in the context of its potential antidepressant, anti-inflammatory, and anti-tumor properties. It is typically used as a research tool in laboratory settings to further investigate its potential therapeutic applications. The hydrochloride salt form of the compound is often used for better solubility and stability in aqueous solutions.

Upstream product

• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 903557-28-8 4-bromo-2,3-dihydro-1H-inden-1-amine 
• 817-95-8 ethyl 2-ethoxyethanoate 
• 3938-96-3 ethyl 2-methoxyacetate 
• 903557-27-7 4-bromo-1-indanone oxime 

Downstream Products

• 1228556-71-5 (S)-4-bromo-2,3-dihydro-1H-inden-1-amine 

Relevant articles and documents

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.

Microwave-accelerated reductive amination between ketones and ammonium acetate

A new procedure for reductive amination between ketones and ammonium acetate has been developed to access a variety of primary amines. This protocol takes advantage of microwave heating to significantly accelerate the reaction and offers a convenient and effective method to access some interesting amines. This new procedure compares favorably to previously reported approaches in terms of practicality, efficiency, and functional group compatibility.

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.