1228557-22-9

Basic information

• Product Name: 2-(4-METHYLPHENYL)PIPERIDINE
• Synonyms: 2-(4-METHYLPHENYL)PIPERIDINE;2-P-TOLYL-PIPERIDINE;(2R)-2-(4-METHYLPHENYL)PIPERIDINE;(R)-2-(4-METHYLPHENYL)PIPERIDINE
• CAS NO: 1228557-22-9
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.27
• Mol File: 1228557-22-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-METHYLPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYLPHENYL)PIPERIDINE(1228557-22-9)
• EPA Substance Registry System: 2-(4-METHYLPHENYL)PIPERIDINE(1228557-22-9)

Safety Data

• Hazardous Substances Data: 1228557-22-9(Hazardous Substances Data)

Usage

General Description

2-(4-methylphenyl)piperidine, also known as 4-Methyl-1-phenylpiperidine, is a chemical compound with the molecular formula C13H17N. It is a piperidine derivative and a psychoactive drug that acts as a stimulant and a nonselective and irreversible monoamine oxidase inhibitor (MAOI). It has been researched for its potential use in the treatment of depression, anxiety, and other mood disorders. It is also used in the synthesis of other pharmaceutical compounds and as a reagent in organic chemical reactions. 2-(4-methylphenyl)piperidine is classified as a controlled substance in certain countries due to its potential for abuse and dependence.

Upstream product

• 105902-02-1 6-p-tolyl-2,3,4,5-tetrahydro-pyridine 
• 833-85-2 5-(4-methylphenyl)-5-oxopentanoic acid 

Relevant articles and documents

Synthesis of chiral cyclic amines via Ir-catalyzed enantioselective hydrogenation of cyclic imines

A highly enantioselective hydrogenation of cyclic imines for synthesis of chiral cyclic amines has been realized. With the complex of iridium and (R,R)-f-spiroPhos as the catalyst, a range of cyclic 2-aryl imines were smoothly hydrogenated under mild conditions without any additive to provide the corresponding chiral cyclic amines with excellent enantioselectivities of up to 98% ee. Moreover, this method could be successfully applied to the synthesis of (+)-(6S,10bR)-McN-4612-Z.

Applications of N′-alkylated derivatives of TsDPEN in the asymmetric transfer hydrogenation of C=O and C=N bonds

Arene/Ru(II) complexes of (R,R)-N-alkyl-TsDPEN ligands are effective in the asymmetric transfer hydrogenation of ketones and imines in formic acid/triethylamine solution. The complex derived from the N′-Bn derivative of TsDPEN reduces monocyclic imines in up to 60% ee, whilst the N′-Me derivative of TsDPEN forms a more active catalyst than the non-alkylated analogue and reduces ketones in up to 97% ee.