1228559-38-3

Basic information

• Product Name: (S)-2-(2-FLUOROPHENYL)PIPERIDINE
• Synonyms: (S)-2-(2-FLUOROPHENYL)PIPERIDINE;(2S)-2-(2-FLUOROPHENYL)PIPERIDINE
• CAS NO: 1228559-38-3
• Molecular Formula: C11H14FN
• Molecular Weight: 179.23
• Mol File: 1228559-38-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 240.4±33.0 °C(Predicted)
• Appearance: /
• Density: 1.048±0.06 g/cm3(Predicted)
• PKA: 9.21±0.10(Predicted)
• CAS DataBase Reference: (S)-2-(2-FLUOROPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2-FLUOROPHENYL)PIPERIDINE(1228559-38-3)
• EPA Substance Registry System: (S)-2-(2-FLUOROPHENYL)PIPERIDINE(1228559-38-3)

Safety Data

• Hazardous Substances Data: 1228559-38-3(Hazardous Substances Data)

Usage

General Description

(S)-2-(2-fluorophenyl)piperidine is a chemical compound that belongs to the category of piperidines, which are heterocyclic organic compounds with a six-membered ring containing one nitrogen atom. It is a chiral molecule with two enantiomers, (S)- and (R)-2-(2-fluorophenyl)piperidine, with the (S)-enantiomer being the biologically active form. (S)-2-(2-FLUOROPHENYL)PIPERIDINE has shown potential in pharmaceutical research, particularly in the development of new drugs for the treatment of various conditions, including central nervous system disorders. Its unique chemical structure and properties make it valuable for studying structure-activity relationships and designing novel therapeutic agents. Additionally, the fluorine substitution on the phenyl ring can potentially alter its pharmacological properties, making it a target for medicinal chemistry research. Overall, (S)-2-(2-fluorophenyl)piperidine is a valuable compound in the field of drug discovery and development.

Relevant articles and documents

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

The imine reductase AoIRED from Amycolatopsis orientalis (Uniprot R4SNK4) catalyzes the NADPH-dependent reduction of a wide range of prochiral imines and iminium ions, predominantly with (S)-selectivity and with ee's of up to >99%. AoIRED displays up to 100-fold greater catalytic efficiency for 2-methyl-1-pyrroline (2MPN) compared to other IREDs, such as the enzyme from Streptomyces sp. GF3546, which also exhibits (S)-selectivity, and thus, AoIRED is an interesting candidate for preparative synthesis. AoIRED exhibits unusual catalytic properties, with inversion of stereoselectivity observed between structurally similar substrates, and also, in the case of 1-methyl-3,4-dihydroisoquinoline, for the same substrate, dependent on the age of the enzyme after purification. The structure of AoIRED has been determined in an "open" apo-form, revealing a canonical dimeric IRED fold in which the active site is formed between the N- and C-terminal domains of participating monomers. Co-crystallization with NADPH gave a "closed" form in complex with the cofactor, in which a relative closure of domains, and associated loop movements, has resulted in a much smaller active site. A ternary complex was also obtained by cocrystallization with NADPH and 1-methyl-1,2,3,4-tetrahydroisoquinoline [(MTQ], and it reveals a binding site for the (R)-amine product, which places the chiral carbon within 4 ? of the putative location of the C4 atom of NADPH that delivers hydride to the C? -N bond of the substrate. The ternary complex has permitted structure-informed mutation of the active site, resulting in mutants including Y179A, Y179F, and N241A, of altered activity and stereoselectivity.

BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE

The invention is directed to inhibitors of mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them. The inhibitors are generally of structural formula wherein the combination of R1 and R2 are