1228561-05-4

Basic information

• Product Name: (R)-1-AMINO-INDAN-4-OL
• Synonyms: (R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-4-OL;(R)-1-AMINO-INDAN-4-OL;(1R)-1-AMINOINDAN-4-OL
• CAS NO: 1228561-05-4
• Molecular Formula: C9H11NO
• Molecular Weight: 149.19
• Product Categories: pharmacetical
• Mol File: 1228561-05-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 274.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.198±0.06 g/cm3(Predicted)
• PKA: 10.24±0.40(Predicted)
• CAS DataBase Reference: (R)-1-AMINO-INDAN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-AMINO-INDAN-4-OL(1228561-05-4)
• EPA Substance Registry System: (R)-1-AMINO-INDAN-4-OL(1228561-05-4)

Safety Data

• Hazardous Substances Data: 1228561-05-4(Hazardous Substances Data)

Usage

General Description

(R)-1-AMINO-INDAN-4-OL, also known as (R)-4-Aminotetralin, is a chemical compound that belongs to the class of amino alcohols. It is a chiral compound with a specific stereochemistry, meaning it has a non-superimposable mirror image. This chemical is used in the synthesis of pharmaceuticals and as a building block in organic chemistry. It has potential applications in the development of drugs for the treatment of various medical conditions. Additionally, (R)-1-AMINO-INDAN-4-OL may be used in research and development efforts focused on discovering new compounds with therapeutic properties. Its unique structural and stereochemical features make it a valuable molecule in medicinal and synthetic chemistry.

Upstream product

• 40731-98-4 4-hydroxy-2,3-dihydroindan-1-one 
• 103441-70-9 4-hydroxy-indan-1-one oxime 
• 103441-70-9 4-hydroxy-indan-1-one oxime 

Downstream Products

• 1201362-27-7 2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant articles and documents

5,7-DIHYDRO-6H-PYRROLO[2,3-D]PYRIMIDIN-6-ONE DERIVATIVES FOR MARK INHIBITION

Compounds of formula I: are potent and selective inhibitors of microtubule affinity regulating kinase (MARK), and hence find use in treatment of Alzheimer's disease and other conditions associated with hyperphosphorylation of tau.

Novel Cerebroprotective Agents with Central Nervous System Stimulating Activity. 1. Synthesis and Pharmacology of 1-Amino-7-hydroxyindan Derivatives

To developed a novel cerebroprotective agent with central nervous system (CNS) stimulating activity, a series of 1-amino-7-hydroxyindan derivatives was synthesized, and their effects on the survival time of mice under hypoxic conditions were tested.CNS-stimulating activity was also evaluated by examining the promotional effect on the recovery from cerebral concussion induced coma in mice.Several compounds prolonged the survival time of mice in hypoxic conditions at a dose of 30 mg/kg (sc or ip) and 100 mg/kg (po).They also exhibited the promotional effects on recovery from coma at a dose of 100 mg/kg po.The three most potent compounds in both tests, 1-amino-7-hydroxy-6-(1-methylpropyl)indan (20), 1-amino-7-hydroxy-4,6-dimethyl-2-phenylindan (30), and 1-amino-7-hydroxy,2,2,4,6-tetramethylindan (35) were selected for further investigations.Structure-activity relationships were also discussed.