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1228561-27-0

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1228561-27-0 Usage

General Description

(1R)-5-Bromoindanylamine is a chemical compound with the molecular formula C9H10BrN. It is an indane derivative with a bromine atom attached to the 5th carbon of the indane ring and an amine functional group. (1R)-5-BROMOINDANYLAMINE is often used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It can also be used in the development of new materials and in chemical research. (1R)-5-Bromoindanylamine may have potential applications in medicinal chemistry and drug discovery due to its unique structure and properties. Overall, it is a valuable chemical building block with a wide range of potential uses in the fields of chemistry and biotechnology.

Check Digit Verification of cas no

The CAS Registry Mumber 1228561-27-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,5,6 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1228561-27:
(9*1)+(8*2)+(7*2)+(6*8)+(5*5)+(4*6)+(3*1)+(2*2)+(1*7)=150
150 % 10 = 0
So 1228561-27-0 is a valid CAS Registry Number.

1228561-27-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-5-bromo-2,3-dihydro-1H-inden-1-amine

1.2 Other means of identification

Product number -
Other names (1R)-5-bromoindan-1-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1228561-27-0 SDS

1228561-27-0Relevant articles and documents

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Ashcraft, Luke,Chin, Eva R.,Chuang, Chihyuan,Collibee, Scott,Cremin, Peadar,Hartman, James,Hwee, Darren T.,Malik, Fady I.,Morgan, Bradley P.,Robertson, Laura A.,Schaletzky, Julia,Vander Wal, Mark,Wang, Jingying,Wang, Wenyue,Wang, Xiaolin,Wehri, Eddie,Wu, Yangsong,Zamora, Jeanelle

supporting information, p. 14142 - 14152 (2021/10/20)

Hypercontractility of the cardiac sarcomere may be essential for the underlying pathological hypertrophy and fibrosis in genetic hypertrophic cardiomyopathies. Aficamten (CK-274) is a novel cardiac myosin inhibitor that was discovered from the optimization of indoline compound 1. The important advancement of the optimization was discovery of an Indane analogue (12) with a less restrictive structure-activity relationship that allowed for the rapid improvement of drug-like properties. Aficamten was designed to provide a predicted human half-life (t1/2) appropriate for once a day (qd) dosing, to reach steady state within two weeks, to have no substantial cytochrome P450 induction or inhibition, and to have a wide therapeutic window in vivo with a clear pharmacokinetic/pharmacodynamic relationship. In a phase I clinical trial, aficamten demonstrated a human t1/2 similar to predictions and was able to reach steady state concentration within the desired two-week window.

USE OF GHRELIN RECEPTOR INVERSE AGONISTS OR ANTAGONISTS FOR TREATING SLEEP DISORDERS

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Page/Page column 17, (2014/01/08)

The present invention relates to methods of treating sleep disorders in patients comprising administration of a ghrelin receptor inverse agonist or antagonist. The invention also includes methods of treating sleep disorders comprising the administration of a pharmaceutical composition comprising a ghrelin receptor inverse agonist or antagonist and at least one pharmaceutically acceptable carrier, diluent, or excipient.

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