1228566-84-4Relevant academic research and scientific papers
New simple synthesis of N-substituted 1,3-oxazinan-2-ones
Trifunovic, Sreko,Dimitrijevic, Dejana,Vasic, Gordana,Radulovic, Niko,Vukicevic, Mirjana,Heinemann, Frank W.,Vukicevic, Rastko D.
, p. 943 - 946 (2010)
An efficient and simple synthesis of N-substituted 1,3-oxazinan-2-ones was developed that involves a three-component, one-pot reaction of readily available tetraethylammonium bicarbonate, 1,3-dibromopropane, and a primary amine in methanol at room temperature. l-Alanine can be used as the amino component to give the chiral product (2S)-2-(2-oxo-1,3-oxazinan-3-yl)propanoic acid. Georg Thieme Verlag Stuttgart ? New York.
